Structure of PDB 8ecc Chain C

Receptor sequence

>8eccC (length=343) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLVL
SATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVD
IILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETW
RLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQ
ELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTE
KLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

8ecc Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA

Chain

Resolution

2.44 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T177 K178 T181
BS02	dna	C	R222 K315 R342	R74 K158 R185
BS03	dna	C	R158 L159 K160 R161 K184 H203 K395	R10 L11 K12 R13 K36 H55 K232
BS04	dna	C	R161 S165 N196 Y200 Y201	R13 S17 N48 Y52 Y53
BS05	VWX	C	G198 S199 E211 D213 P292 D307 I309 K350 R364 S366 S368 K402 C419 S420 Y421	G50 S51 E63 D65 P135 D150 I152 K193 R201 S203 S205 K239 C256 S257 Y258
BS06	MG	C	E211 D213	E63 D65
BS07	ZN	C	H378 C384 C385 C392	H215 C221 C222 C229

External links

PDB	RCSB:8ecc, PDBe:8ecc, PDBj:8ecc
PDBsum	8ecc
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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