Structure of PDB 8e96 Chain C

Receptor sequence
>8e96C (length=721) Species: 9606 (Homo sapiens) [Search protein sequence]
KIVNIGAVLSTRKHEQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM
ALSVCEDLISSQVYAILVSHPPTPNDHFTPTPVSYTAGFYRIPVLGLTTR
MSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGR
AAQKRLETLLEERESKAEKVLQFDPGTKNVTALLMEAKELEARVIILSAS
EDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLING
KNESAHISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRV
LMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNGTHVIP
NDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEF
TVNGDPVKKVICTGPHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGK
FGTQERKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLT
ILVKKEIPSFMQPFQSTLWLLVGLSVHVVAVMLLSSAMWFSWGVLLNSGR
SFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNP
SDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNK
LHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLS
ILKSHENGFMEDLDKTWVRYQ
3D structure
PDB8e96 Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.
ChainC
Resolution3.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY C F484 T518 R523 D732 F451 T479 R484 D657
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding
GO:0004972 NMDA glutamate receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0015276 ligand-gated monoatomic ion channel activity
GO:0015280 ligand-gated sodium channel activity
GO:0016594 glycine binding
GO:0016595 glutamate binding
GO:0022849 glutamate-gated calcium ion channel activity
GO:0038023 signaling receptor activity
GO:0044877 protein-containing complex binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0007268 chemical synaptic transmission
GO:0007420 brain development
GO:0008542 visual learning
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0018964 propylene metabolic process
GO:0019722 calcium-mediated signaling
GO:0034220 monoatomic ion transmembrane transport
GO:0035235 ionotropic glutamate receptor signaling pathway
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0045471 response to ethanol
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048167 regulation of synaptic plasticity
GO:0048168 regulation of neuronal synaptic plasticity
GO:0051290 protein heterotetramerization
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0055074 calcium ion homeostasis
GO:0060079 excitatory postsynaptic potential
GO:0070588 calcium ion transmembrane transport
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098655 monoatomic cation transmembrane transport
GO:0098976 excitatory chemical synaptic transmission
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1904062 regulation of monoatomic cation transmembrane transport
GO:1904646 cellular response to amyloid-beta
GO:1905429 response to glycine
GO:2000463 positive regulation of excitatory postsynaptic potential
Cellular Component
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0009986 cell surface
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0017146 NMDA selective glutamate receptor complex
GO:0030425 dendrite
GO:0043005 neuron projection
GO:0043083 synaptic cleft
GO:0043195 terminal bouton
GO:0043197 dendritic spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
GO:0097060 synaptic membrane
GO:0098839 postsynaptic density membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8e96, PDBe:8e96, PDBj:8e96
PDBsum8e96
PubMed36309015
UniProtQ05586|NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (Gene Name=GRIN1)

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