Structure of PDB 8e6t Chain C

Receptor sequence

>8e6tC (length=1290) Species: 9606 (Homo sapiens)

QESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQHLEEATKP
HTFQGTQWDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIY
HLMTQHWGLDVPNLLISVTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWI
ITGGSHTGVMKQVGEAVRDFSLSSSYKEGELITIGVATWGTVHRREGLIH
PTGSFPAEYILDEDGQGNLTCLDSNHSHFILVDDGTHGQYGVEIPLRTRL
EKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCVVVEG
SGRVADVIAQVANIPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKK
IQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQ
LKLAVAWNRVDIARSEIFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLE
NGVQLKEFVTWDTLLYLYENLDPSCLFHSKLQKVLVEDPERPACAPAAPR
LQMHHVAQVLRELLGDFTQPLYPRPRHVTFTMDPIRDLLIWAIVQNRREL
AGIIWAQSQDCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAI
GVFTECYRKDEERAQKLLTRVSEAWGKTTCLQLALEAKDMKFVSHGGIQA
FLTKVWWGQLSVDNGLWRVTLCMLAFPLLLTGLISFREKRLQDVGTPAAR
ARAFFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPVPSWCECAIYLWLF
SLVCEEMRQLFYDPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL
IPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFF
LFLLAVWVVSFGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGYLLFTNI
LLLNLLIAMFNYTFQQVQEHTDQIWKFQRHDLIEEYHGRPAAPPPFILLS
HLQLFIKRVVRHKQLKNKLEKNEEAALLSWEIYLKENYLQNRQFQQKQRP
EQKIEDISNKVDAMVDLLDLDGDSYHVNARHLLYPNCPVTRFPVPNEKVP
WETEFLIYDPPFYTAERKDAAAMDPMGDTLEPLSTIQYNVVDGLRDRRSF
HGPYTVQAGLPLNPMGRTGLRGRGSLSCFGPNHTLYPMVTRWRRNEDGAI
CRKSIKKMLEVLVVKLPLSEHWALPGGSREPGEMLPRKLKRILRQEHWPS
FENLLKCGMEVYKGYMDDPRNTDNAWIETVAVSVHFQDQNDVELNRLNSN
LHACDSGASIRWQVVDRRIPLYANHKTLLQKAAAEFGAHY

3D structure

• PDB: 8e6t A unified mechanism for human TRPM2 activation, desensitization and inhibition
• Chain: C
• Resolution: 3.7 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	UOO	C	T174 G175 G176 A177 K178 S210 Y295 I299 R302 G333 P334 G335	T119 G120 G121 A122 K123 S155 Y240 I244 R247 G278 P279 G280
BS02	UOO	C	P1432 R1433 Y1485	P1219 R1220 Y1272

External links

• PDB: RCSB:8e6t, PDBe:8e6t, PDBj:8e6t
• PDBsum: 8e6t
• UniProt: O94759|TRPM2_HUMAN Transient receptor potential cation channel subfamily M member 2 (Gene Name=TRPM2)