Structure of PDB 8dwl Chain C

Receptor sequence

>8dwlC (length=294) Species: 9606 (Homo sapiens)

SLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLEL
EAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETIC
LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDC
FNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
WSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGY
EFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA

3D structure

• PDB: 8dwl Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction.
• Chain: C
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.1.3.16: protein-serine/threonine phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	R96 D166 I169 D208 R221 D242 L243 Q249 V250 E252 D253 Y255 F257 F258 A259 K260 R261 F276 E287 L289 M290 C291 F293	R91 D161 I164 D203 R216 D237 L238 Q244 V245 E247 D248 Y250 F252 F253 A254 K255 R256 F271 E282 L284 M285 C286 F288
BS02	ZN	C	D64 H66 D92	D59 H61 D87
BS03	ZN	C	D92 N124 H173 H248	D87 N119 H168 H243

Gene Ontology

Molecular Function

• GO:0016787 hydrolase activity

External links

• PDB: RCSB:8dwl, PDBe:8dwl, PDBj:8dwl
• PDBsum: 8dwl
• PubMed: 37002212
• UniProt: P62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)