Structure of PDB 8dsg Chain C

Receptor sequence
>8dsgC (length=445) Species: 1404 (Priestia megaterium) [Search protein sequence]
TIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTR
YLSSQRLIKEACDESRFDKTLSQGLKFLRDFLGDGLATSWTHEKNWKKAH
NILLPSFSQQAMKGYHASMVDIAVQLVQKWERLNADEHIEVSEDMTRLTL
DTIGLCGFNYRFNSFYRDQPHPFIISMVRALDEVMNKLQRPDDPAYDENK
RQFQEDIKVMNDLVDKIIADRKATDDLLTQMLNGKDPETGEPLDDGNIRY
QIITFLYAGVEGTSGLLSFALYFLVKNPHVLQKVAEEAARVLVDPVPSYK
QVKQLKYVGMVLNEALRLWPVVPVFSLYAKEDTVLGGEYPLEKGDEVMVL
IPQLHRDKTVWGDDVEEFRPERFEIPQHAFKPFGNGQRASPGQQFALHEA
TLVLGMMLKHFDFEDHTNYELDIKELQTLKPKGFVVKAKSKKIPL
3D structure
PDB8dsg Chemodivergent C(sp3)-H and C(sp2)-H cyanomethylation using engineered carbene transferases
ChainC
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.14.1: unspecific monooxygenase.
1.6.2.4: NADPH--hemoprotein reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C K69 L86 W96 F261 A264 V328 F331 P392 F393 G394 R398 S400 P401 G402 K69 L86 W96 F255 A258 V322 F325 P382 F383 G384 R388 S390 P391 G392
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding

View graph for
Molecular Function
External links
PDB RCSB:8dsg, PDBe:8dsg, PDBj:8dsg
PDBsum8dsg
PubMed36875868
UniProtP14779|CPXB_PRIM2 Bifunctional cytochrome P450/NADPH--P450 reductase (Gene Name=cyp102A1)

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