Structure of PDB 8dsf Chain C

Receptor sequence
>8dsfC (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
SISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCC
DGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRY
3D structure
PDB8dsf A covalent BTK ternary complex compatible with targeted protein degradation
ChainC
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TO0 C Y278 W279 P280 S281 G299 Y19 W20 P21 S22 G40
BS02 ZN C C306 C309 H326 C333 C47 C50 H67 C74
BS03 TO0 C D303 G312 L313 R314 C315 W316 D320 E325 W329 D44 G53 L54 R55 C56 W57 D61 E66 W70
External links
PDB RCSB:8dsf, PDBe:8dsf, PDBj:8dsf
PDBsum8dsf
PubMed36864023
UniProtQ13490|BIRC2_HUMAN Baculoviral IAP repeat-containing protein 2 (Gene Name=BIRC2)

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