Structure of PDB 8c60 Chain C

Receptor sequence
>8c60C (length=213) Species: 9606 (Homo sapiens) [Search protein sequence]
SGGLMEQIQALLAPPKTDDSCDSCKEGGDLLCCDHCPAAFHLQCCNPPLS
EEMLPPGEWMCHRCTVRRKKREQKPQLRRPFELLIAAAMERNPTQFQLPN
ELTCTTQHELDHNGLVPLPVKVCFTCNRSCRVAPLIQCDYCPLLFHMDCL
EPPLTAMPLGRWMCPNHIEHVVLNQKNMTLSNRCQVFDRFQDTVSQHVVK
VDFLNRIHKKHPP
3D structure
PDB8c60 Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex.
ChainC
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C289 C315 H318 C138 C164 H167
BS02 ZN C C274 C277 H297 C300 C123 C126 H146 C149
BS03 ZN C C71 C74 C99 C102 C33 C36 C61 C64
BS04 ZN C C59 H79 C82 C21 H41 C44
Gene Ontology
Molecular Function
GO:0001222 transcription corepressor binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0017053 transcription repressor complex
GO:0070822 Sin3-type complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c60, PDBe:8c60, PDBj:8c60
PDBsum8c60
PubMed37137925
UniProtQ96QT6|PHF12_HUMAN PHD finger protein 12 (Gene Name=PHF12)

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