Structure of PDB 8blp Chain C

Receptor sequence

>8blpC (length=355) Species: 9606 (Homo sapiens)

FPKALGYVTGDMKELANQLKDKPVVLQFIDWILRGISQVVFVNNPVSGIL
ILVGLLVQNPWWALTGWLGTVVSTLMALLLSQDRSLIASGLYGYNATLVG
VLMAVFSDKGDYFWWLLLPVCAMSMTCPIFSSALNSVLSKWDLPVFTLPF
NMALSMYLSATGHYNPFFPAKLVIPITTAPQISWSDLSALELLKSIPVGV
GQIYGCDNPWTGGIFLGAILLSSPLMCLHAAIGSLLGIAAGLSLSAPFEN
IYFGLWGFNSSLACIAMGGMFMALTWQTHLLALGCALFTAYLGVGMANFM
AEVGLPACTWPFCLATLLFLIMTTKNSNIYKMPLSKVTYPEENRIFYLQA
KKRMV

3D structure

• PDB: 8blp Structural characterization of human urea transporters UT-A and UT-B and their inhibition.
• Chain: C
• Resolution: 2.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	C	M106 L109 L110 T156	M76 L79 L80 T126
BS02	Y01	C	W306 Q307 L310 L311 G314 F349	W276 Q277 L280 L281 G284 F319
BS03	5D3	C	L132 F136 Q232 F283 L285 W286 F288 V324 P336 A337 C338	L102 F106 Q202 F253 L255 W256 F258 V294 P306 A307 C308
BS04	5D3	C	Q68 V69 F71 L121 Y122 Y124 S161 N165 P174 V175 F176 M300 F342 V367	Q38 V39 F41 L91 Y92 Y94 S131 N135 P144 V145 F146 M270 F312 V337

Gene Ontology

Molecular Function

• GO:0005372 water transmembrane transporter activity
• GO:0015204 urea transmembrane transporter activity
• GO:0015265 urea channel activity

Biological Process

• GO:0006833 water transport
• GO:0015840 urea transport
• GO:0051649 establishment of localization in cell
• GO:0055085 transmembrane transport
• GO:0071918 urea transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0016323 basolateral plasma membrane

External links

• PDB: RCSB:8blp, PDBe:8blp, PDBj:8blp
• PDBsum: 8blp
• PubMed: 37774028
• UniProt: Q13336|UT1_HUMAN Urea transporter 1 (Gene Name=SLC14A1)