Structure of PDB 8bix Chain C

Receptor sequence
>8bixC (length=396) Species: 5811 (Toxoplasma gondii) [Search protein sequence]
VKAGDWLPGFTPREETVYVHGGVEPDPLTGAILPPIYQNTTFVQESVENY
LSKGFSYSRTSNPTVLSLEKKIAEIEGGFGACCFATGMAATVTIFSAFLA
PGDHCLVTNCSYGGTNRCARLHFSKYNIDFEFIDFRDPTNVEKAIRPQTK
VVFSESPCNPTLYLADIEAISQICKEKKVLHVCDSTFATPYMMRPLDLGA
DIVVQSTTKYYDGHNCTLGGAVISSTKEIHDKVFFLRNVMGNIMSAQTAF
YTLLTLKTLPIRVEKQSANAQKIAEFLSKHHKVEHVIYPGIPSFPQKELA
LKQHKNVHGGMLAFEVKGGTEAGIRMMNHVPRPWSLCESLGACESIITCP
AVFTHANMLREDRLKVGITDGFIRVSVGIEDVNDLIDGLDYALSKA
3D structure
PDB8bix Structural basis of the inhibition of cystathionine gamma-lyase from Toxoplasma gondii by propargylglycine and cysteine.
ChainC
Resolution1.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.1: cystathionine gamma-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP C G108 M109 Y133 D205 F208 S227 T229 K230 G87 M88 Y112 D184 F187 S206 T208 K209
BS02 PLP C Y78 R80 Y57 R59
Gene Ontology
Molecular Function
GO:0004123 cystathionine gamma-lyase activity
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0019346 transsulfuration
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bix, PDBe:8bix, PDBj:8bix
PDBsum8bix
PubMed36883335
UniProtB6K8Y1

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