Structure of PDB 8be0 Chain C

Receptor sequence

>8be0C (length=731) Species: 1601067 (Influenza B virus (B/Memphis/13/2003)) [Search protein sequence]

MTLAKIELLKQLLRDNEAKTVLKQTTVDQYNIIRKFNTSRIEKNPSLRMK
WAMCSNFPLALTKGDMANRIPLEYKGIQLKTNKGQMCSIAAVTWWNTYGP
IGDTEGFERVYESFFLRKMRLDNATWGRITFGPVERVRKRVLLNPLTKEM
PPDEASNVIMEILFPKEAGIPRESTWIHRELIKEKREKLKGTMITPIVLA
YMLERELVARRRFLPVAGATSAEFIEMLHCLQGENWRQIYHPGGNKLTES
RSQSMIVACRKIIRRSIVASNPLELAVEIANKTVIDTEPLKSCLAAIDGG
DVACDIIRAALGLKIRQRQRFGRLELKRISGRGFKNDEEILIGNGTIQKI
GIWDGEEEFHVRCGECRGILKKSKMKLEKLLINSAKKEDMRDLIILCMVF
SQDTRMFQGVRGEINFLNRAGQLLSPMYQLQRYFLNRSNDLFDQWGYEES
PKASELHGINESMNASDYTLKGVVVTRNVIDDFSTEKVSITKNLSLIKRT
GEVIMGANDVSELESQAQLMITYDTPKMWEMGTTKELVQNTYQWVLKNLV
TLKAQFLLGKEDMFQWDAFEAFESIIPQKMAGQYSGFARAVLKQMRDQEV
MKTDQFIKLLPFCFSPPKLRSNGEPYQFLKLVLKGGGENFIEVRKGSPLF
SYNPQTEVLTICGRMMSLKGKIEDEERNRSMGNAVLAGFLVSGKYDPDLG
DFKTIEELEKLKPGEKANILLYQGKPVKVVK

3D structure

PDB

8be0 Direct observation of backtracking by influenza A and B polymerases upon consecutive incorporation of the nucleoside analog T1106.

Chain

Resolution

2.34 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	C	R40 K43 I203 Y207 R216 R218 R425	R40 K43 I197 Y201 R210 R212 R419
BS02	rna	C	K35 P45 R146 P158 D159 Y207 R217 Q259 L430 Y434 Q435 R438 S524	K35 P45 R140 P152 D153 Y201 R211 Q253 L424 Y428 Q429 R432 S515
BS03	GTA	C	I262 R266 G306 Q325 R326 K341 W359 F406 S520 L522	I256 R260 G300 Q319 R320 K335 W353 F400 S511 L513

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003968	RNA-dependent RNA polymerase activity

	Biological Process
GO:0001172	RNA-templated transcription
GO:0006351	DNA-templated transcription
GO:0006370	7-methylguanosine mRNA capping
GO:0019083	viral transcription
GO:0039523	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694	viral RNA genome replication
GO:0075526	cap snatching

	Cellular Component
GO:0033650	host cell mitochondrion
GO:0042025	host cell nucleus
GO:0044423	virion component

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8be0, PDBe:8be0, PDBj:8be0
PDBsum	8be0
PubMed	36596301
UniProt	Q5V8X3

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