Structure of PDB 8b9n Chain C

Receptor sequence
>8b9nC (length=236) Species: 10090 (Mus musculus) [Search protein sequence]
MVEGPGCTLNGEKIRARVLPGQAVTGVRGTALVYSGVETLGKELFMYFGH
RALRIHFGMKGSILINPSPALAVQLTRDLICFYDSSVELRNSVESQQRVR
EMEELDICSPKFSFSRAESEVKKQGDRMLCDVLLDQRVLPGVGNIIKNEA
LFDSGLHPAVKVCQLSDKQARHLVKMTRDFSILFYRCCKAGSAISKHCKV
YKRPNCGQCHSKITVCRFGENSRMTYFCPHCQKDGL
3D structure
PDB8b9n Crystal structure of NEI domain of mouse NEIL3 trapped in covalent complex with ssDNA with abasic site
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C M1 V2 E3 K82 R94 H96 M99 Q185 N193 I194 Y250 R272 M1 V2 E3 K42 R54 H56 M59 Q136 N144 I145 Y201 R223
BS02 ZN C C255 C258 C277 C280 C206 C209 C228 C231
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8b9n, PDBe:8b9n, PDBj:8b9n
PDBsum8b9n
PubMed
UniProtQ8K203|NEIL3_MOUSE Endonuclease 8-like 3 (Gene Name=Neil3)

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