Structure of PDB 8b6m Chain C

Receptor sequence
>8b6mC (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAM
3D structure
PDB8b6m Tankyrase 2 in complex with an inhibitor
ChainC
Resolution1.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1081 H1084 C1089 C1092 C130 H133 C138 C141
BS02 OY6 C H1031 G1032 P1034 F1035 A1038 G1043 F1044 D1045 H1048 Y1050 I1059 Y1060 F1061 A1062 K1067 S1068 Y1071 I1075 H80 G81 P83 F84 A87 G92 F93 D94 H97 Y99 I108 Y109 F110 A111 K116 S117 Y120 I124
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:8b6m, PDBe:8b6m, PDBj:8b6m
PDBsum8b6m
PubMed
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

[Back to BioLiP]