Structure of PDB 8b2n Chain C

Receptor sequence
>8b2nC (length=156) Species: 9606 (Homo sapiens) [Search protein sequence]
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTG
MADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTT
HSTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRG
IQSLYG
3D structure
PDB8b2n A unique network of attack, defence and competence on the outer membrane of the periodontitis pathogen Tannerella forsythia.
ChainC
Resolution1.85 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.24.65: macrophage elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C D124 E199 E201 D19 E94 E96
BS02 CA C D158 G190 G192 D194 D53 G85 G87 D89
BS03 CA C D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96
BS04 ZN C H168 D170 H183 H196 H63 D65 H78 H91
BS05 ZN C H218 H222 H228 H111 H115 H121
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b2n, PDBe:8b2n, PDBj:8b2n
PDBsum8b2n
PubMed36755705
UniProtP39900|MMP12_HUMAN Macrophage metalloelastase (Gene Name=MMP12)

[Back to BioLiP]