Structure of PDB 8avg Chain C

Receptor sequence
>8avgC (length=435) Species: 10090 (Mus musculus) [Search protein sequence]
SGIAVVAVMCKPHRCPHISFTGNICIYCPGGPDSDFEYSTQSYTGYEPTS
MRAIRARYDPFLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEEYRDY
FIRSLHDALSGHTSNNIHEAIKYSERSFTKCVGITIETRPDYCMKRHLSD
MLTYGCTRLEIGVQSVYEDVARDTNRGHTVKAACESFHLAKDSGFKVVTH
MMPDLPNVGLERDIEQFIEFFENPAFRPDGLKLYPTLVIRGTGLYELWKS
GRYRSYSPSDLIELVARILALVPPWTRVYRVQRDIPMPLVSSGVEHGNLR
ELAFARMKDLGIQCRDVRTREVYQVELVRRDYVANGGWETFLSYEDPDQD
ILIGLLRLRKCSEETFRFELGGGVSIVRELHVYGGFGMLLMEEAERIARE
EHGSGKMAVISGVGTRNYYRKIGYRLQGPYMVKML
3D structure
PDB8avg Cryo-EM structure of the fully assembled Elongator complex.
ChainC
Resolution4.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.311: tRNA carboxymethyluridine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 C C99 H101 I108 C109 C112 Q125 S126 R223 C15 H17 I24 C25 C28 Q41 S42 R139
BS02 SAM C Y111 Q248 H284 M286 Y318 L321 R367 Y27 Q164 H200 M202 Y234 L237 R283
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003824 catalytic activity
GO:0008607 phosphorylase kinase regulator activity
GO:0016407 acetyltransferase activity
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0106261 tRNA uridine(34) acetyltransferase activity
Biological Process
GO:0001764 neuron migration
GO:0002098 tRNA wobble uridine modification
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0008033 tRNA processing
GO:0030335 positive regulation of cell migration
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8avg, PDBe:8avg, PDBj:8avg
PDBsum8avg
PubMed36617428
UniProtQ9CZX0|ELP3_MOUSE Elongator complex protein 3 (Gene Name=Elp3)

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