Structure of PDB 8asw Chain C

Receptor sequence

>8aswC (length=527) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

PEKERFIQCCADITLELTDSLTSGTTREINLNGLITKYSKKYKLKQQPRL
TDIINSIPDQYKKYLLPKLKAKPVRTASGIAVVAVMCKPHRCPHIAYTGN
ICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYDPYEQARGRVEQLKQ
LGHSIDKVEYVLMGGTFMSLPKEYREDFIVKLHNALSGFNGNDIDEAILY
SQQSLTKCVGITIETRPDYCTQTHLDDMLKYGCTRLEIGVQSLYEDVARD
TNRGHTVRSVCETFAVSKDAGYKVVSHMMPDLPNVGMERDIEQFKEYFEN
PDFRTDGLKIYPTLVIRGTGLYELWKTGRYKSYSANALVDLVARILALVP
PWTRIYRVQRDIPMPLVTSGVDNGNLRELALARMKDLGTTCRDVRTREVG
IQEVHHKVQPDQVELIRRDYYANGGWETFLSYEDPKKDILIGLLRLRKAS
KKYTYRKEFTSQRTSIVRELHVYGHQGFGTLLMEEAERIAKEEHGSEKIS
VISGVGVRNYYGKLGYELDGPYMSKRI

3D structure

PDB

8asw Cryo-EM structure of the fully assembled Elongator complex.

Chain

Resolution

3.96 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.311: tRNA carboxymethyluridine synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	C	T52 K53 K59 Q63 R65 L66 R91 V98 Y136 P141 T142 R160 L167 M179 R370 R373 R376 D377 R393 E394 R411	T36 K37 K43 Q47 R49 L50 R75 V82 Y120 P125 T126 R144 L151 M163 R354 R357 R360 D361 R377 E378 R395
BS02	SF4	C	C108 H110 I117 C118 C121 R232 R269	C92 H94 I101 C102 C105 R216 R253

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003824	catalytic activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0016746	acyltransferase activity
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding
GO:0106261	tRNA uridine(34) acetyltransferase activity

	Biological Process
GO:0002098	tRNA wobble uridine modification
GO:0002926	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417	regulation of translation
GO:0008033	tRNA processing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0033588	elongator holoenzyme complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:8asw, PDBe:8asw, PDBj:8asw
PDBsum	8asw
PubMed	36617428
UniProt	Q02908\|ELP3_YEAST Elongator complex protein 3 (Gene Name=ELP3)

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