Structure of PDB 8asv Chain C

Receptor sequence
>8asvC (length=464) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SGIAVVAVMCKPHRCPHIAYTGNICVYCPGGPDSDFEYSTQSYTGYEPTS
MRAIRARYDPYEQARGRVEQLKQLGHSIDKVEYVLMGGTFMSLPKEYRED
FIVKLHNALSGFNGNDIDEAILYSQQSLTKCVGITIETRPDYCTQTHLDD
MLKYGCTRLEIGVQSLYEDVARDTNRGHTVRSVCETFAVSKDAGYKVVSH
MMPDLPNVGMERDIEQFKEYFENPDFRTDGLKIYPTLVIRGTGLYELWKT
GRYKSYSANALVDLVARILALVPPWTRIYRVQRDIPMPLVTSGVDNGNLR
ELALARMKDLGTTCRDVRTREVGIQEVHHKVQPDQVELIRRDYYANGGWE
TFLSYEDPKKDILIGLLRLRKASKKYTYRKEFTSQRTSIVRELHVYGSVV
PLHSRDPRKFQHQGFGTLLMEEAERIAKEEHGSEKISVISGVGVRNYYGK
LGYELDGPYMSKRI
3D structure
PDB8asv Cryo-EM structure of the fully assembled Elongator complex.
ChainC
Resolution4.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.311: tRNA carboxymethyluridine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SF4 C C108 H110 I117 C118 C121 Q134 C15 H17 I24 C25 C28 Q41
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003824 catalytic activity
GO:0004402 histone acetyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0106261 tRNA uridine(34) acetyltransferase activity
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
GO:0006417 regulation of translation
GO:0008033 tRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0033588 elongator holoenzyme complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8asv, PDBe:8asv, PDBj:8asv
PDBsum8asv
PubMed36617428
UniProtQ02908|ELP3_YEAST Elongator complex protein 3 (Gene Name=ELP3)

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