Structure of PDB 8aht Chain C

Receptor sequence

>8ahtC (length=136) Species: 5833 (Plasmodium falciparum)

DKLTEEQISEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDM
INEIDTDGNGTIDFPEFLTLMARKELIEAFRVFDRDGDGYISADELRHVM
TNLGEKLTNEEVDEMIREADIDGDGQINYEEFVKMM

3D structure

• PDB: 8aht Structures of calmodulin-melittin complexes show multiple binding modes lacking classical anchoring interactions.
• Chain: C
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	E11 E14 F19 M36 L39 Q41 E54 L71 M72 K75 L85 A88 M109 L116 E120 M124 E127	E10 E13 F18 M35 L38 Q40 E53 L70 M71 K74 L76 A79 M100 L107 E111 M115 E118
BS02	CA	C	D20 D22 D24 T26 E31	D19 D21 D23 T25 E30
BS03	CA	C	D56 D58 N60 T62 E67	D55 D57 N59 T61 E66
BS04	CA	C	D93 D95 D97 Y99 E104	D84 D86 D88 Y90 E95
BS05	CA	C	D129 D131 D133 Q135 E140	D120 D122 D124 Q126 E131

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0008047 enzyme activator activity
• GO:0046872 metal ion binding
• GO:0061891 calcium ion sensor activity

Cellular Component

• GO:0005737 cytoplasm
• GO:0020007 apical complex

External links

• PDB: RCSB:8aht, PDBe:8aht, PDBj:8aht
• PDBsum: 8aht
• PubMed: 36906144
• UniProt: P62203|CALM_PLAF7 Calmodulin (Gene Name=CAM)