Structure of PDB 8a4d Chain C

Receptor sequence
>8a4dC (length=563) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
TLHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQT
GGHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMG
TLRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKS
VAVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMGPGTLFEELGWNY
IGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPIGYHA
ITKLEATGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSERY
PERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDVAV
QHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDELRK
LLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVALL
VFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIEEN
AVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLDAA
GIEKAVRQRLDRQ
3D structure
PDB8a4d 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 26G C H115 H157 S158 H301 M346 I368 E370 F395 R398 H84 H126 S127 H249 M287 I309 E311 F336 R339
BS02 MG C D187 N216 D156 N185
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a4d, PDBe:8a4d, PDBj:8a4d
PDBsum8a4d
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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