Structure of PDB 8a49 Chain C

Receptor sequence
>8a49C (length=884) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
EKIPMKPLHGPLYGGYFRTWHDKTSDPTEKDKVNSMGELPKEVDLAFIFH
DWTKDYSLFWKELATKHVPKLNKQGTRVIRTIPWRFLAGGDNSGIAEDTS
KYPNTPEGNKALAKAIVDEYVYKYNLDGLDVAVLHDSIPKVDKKEDTAGV
ERSIQVFEEIGKLIGPKGVDKSRLFIMDSTYMADKNPLIERGAPYINLLL
VQVYGSQGEKGGWEPVSNRPEKTMEERWQGYSKYIRPEQYMIGFSFYEEN
AQEGNLWYDINSRKDEDKANGINTDITGTRAERYARWQPKTGGVKGGIFS
YAIDRDGVAHQPKKYAKQKEFKDATDNIFHSDYSVSKALKTVMLKDKSYD
LIDEKDFPDKALREAVMAQVGTRKGDLERFNGTLRLDNPAIQSLEGLNKF
KKLAQLDLIGLSRITKLDRSVLPANMKPGKDTLETVLETYKEPATIPPVS
LKVSGLTGLKELDLSGFDRETLAGLDAATLTSLEKVDISGNKLDLAPGTE
NRQIFDTMLSTISNHVGSNEQTVKFDKQKPTGHYPDTYGKTSLRLPVANE
KVDLQSQLLFGTVTNQGTLINSEADYKAYQNHKIAGRSFVDSNYHYNNFK
VSYENYTVKVTDSTLGTTTDKTLATDKEETYKVDFFSPADKTKAVHTAKV
IVGDEKTMMVNLAEGATVIGGSADPVNARKVFDGQLGSETDNISLGWDSK
QSIIFKLKEDGLIKHWRFFNDSARNPETTNKPIQEASLQIFNIKDYNLDN
LLENPNKFDDEKYWITVDTYSAQGERATAFSNTLNNITSKYWRVVFDTKG
DRYSSPVVPELQILGYPLPNADTIMKTVTTAKELSQQKDKFSQKMLDELK
IKEMALETSLNSKIFDVTAINANAGVLKDCIEKR
3D structure
PDB8a49 Extensive substrate recognition by the streptococcal antibody-degrading enzymes IdeS and EndoS.
ChainC
Resolution3.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.96: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA C W121 F150 D152 W153 E349 Y402 W20 F49 D51 W52 E248 Y301
BS02 MAN C W121 E349 E350 W20 E248 E249
BS03 MAN C R186 D237 S238 R85 D136 S137
BS04 FUC C Q303 V304 Y305 Q308 Q202 V203 Y204 Q207
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005509 calcium ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
Biological Process
GO:0042783 evasion of host immune response
Cellular Component
GO:0005576 extracellular region
GO:0043655 host extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a49, PDBe:8a49, PDBj:8a49
PDBsum8a49
PubMed36528711
UniProtQ99Y92|ENDOS_STRP1 Endo-beta-N-acetylglucosaminidase EndoS (Gene Name=endoS)

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