Structure of PDB 7zgs Chain C

Receptor sequence
>7zgsC (length=332) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
FYINSKYKIDLDKIMTKMKNKSVINIDDVDDEELLAILYTSKQFEKILKN
NEDSKYLENKVFCSVFLEPSTRTRCSFDAAILKLGSKVLNITDMNSTSFY
KGETVEDAFKILSTYVDGIIYRDPSKKNVDIAVSSSSKPIINAGNGTGEH
PTQSLLDFYTIHNYFPFILDRNINKKLNIAFVGDLKNGRTVHSLSKLLSR
YNVSFNFVSCKSLNIPKDIVNTITYNLKKNNFYSDDSIKYFDNLEEGLED
VHIIYMTRIQNAFILSNKTLENTRDDTKILHPLPRVNEIKVEVDSNPKSV
YFTQAENGLYVRMALLYLIFSSTSSAWSHPQF
3D structure
PDB7zgs Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.
ChainC
Resolution2.349 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.3.2: aspartate carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRA C T108 R109 T71 R72
BS02 PRA C F136 I148 F99 I111
Gene Ontology
Molecular Function
GO:0004070 aspartate carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006520 amino acid metabolic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zgs, PDBe:7zgs, PDBj:7zgs
PDBsum7zgs
PubMed36195578
UniProtA0A5K1K910

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