Structure of PDB 7z84 Chain C

Receptor sequence

>7z84C (length=586) Species: 469008 (Escherichia coli BL21(DE3))

EPAWQTRDHLDDPVIGELRNRFGPDAFTVQATRTGVPVVWIKREQLLEVG
DFLKKLPKPYVMLFDLHGMDERLRTHREGLPAADFSVFYHLISIDRNRDI
MLKVALAENDLHVPTFTKLFPNANWYERETWDLFGITFDGHPNLRRIMMP
QTWKGHPLRKDYPARATEFSPFELTKAKQDLEMEALTFKPEEWGMKRNED
FMFLNLGPNHPSAHGAFRIVLQLDGEEIVDCVPDIGYHHRGAEKMGERQS
WHSYIPYTDRIEYLGGCVNEMPYVLAVEKLAGITVPDRVNVIRVMLSELF
RINSHLLYISTFIQDVGAMTPVFFAFTDRQKIYDLVEAITGFRMHPAWFR
IGGVAHDLPRGWDRLLREFLDWMPKRLASYEKAALQNTILKGRSQGVAAY
GAKEALEWGTTGAGLRATGIDFDVRKARPYSGYENFDFEIPVGGGVSDCY
TRVMLKVEELRQSLRILEQCLNNMPEGPFKADHPLTTPPPKERTLQHIET
LITHFLQVSWGPVMPANESFQMIEATKGINSYYLTSDGSTMSYRTRIRTP
SYAHLQQIPAAIRGSLVSDLIVYLGSIDFVMSDVDR

3D structure

• PDB: 7z84 A universal coupling mechanism of respiratory complex I.
• Chain: C
• Resolution: 2.87 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	C	R254 H359	R240 H345

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003954 NADH dehydrogenase activity
• GO:0005515 protein binding
• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0048038 quinone binding
• GO:0050136 NADH:ubiquinone reductase (non-electrogenic) activity
• GO:0051287 NAD binding

Biological Process

• GO:0022904 respiratory electron transport chain
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0030964 NADH dehydrogenase complex
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:7z84, PDBe:7z84, PDBj:7z84
• PDBsum: 7z84
• PubMed: 36104567
• UniProt: P33599|NUOCD_ECOLI NADH-quinone oxidoreductase subunit C/D (Gene Name=nuoC)