Structure of PDB 7y8l Chain C

Receptor sequence
>7y8lC (length=286) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
RPAPLTLIGLGPMGQAMGNALLDRGHGLTVWNRTASRADALVERGAVRAP
DVAAAVAANELVVLSLTDYDAMYALLGPAADALAGKVVVNLSSDTPEKTR
AGARWIAEHGGTLIAGGVTCPPSGIGSPESSAFYSGPSAAFERHRETLRT
LTRTDYRGEDPGLAALWYQIGMVMWWNAMLGYLQAVALADANGLKAADIL
PHASDTVAGLPFFLRFYADRIDTGHHGGDADRLAMGTASVEHILHTMADS
GVDTALPEAVVAFFRRGEAAGYAENSFSSMVELLKK
3D structure
PDB7y8l Engineered Imine Reductase for Larotrectinib Intermediate Manufacture
ChainC
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C P14 M15 N34 R35 T36 R39 S67 L68 T69 A73 L77 S95 C122 Y170 P12 M13 N32 R33 T34 R37 S65 L66 T67 A71 L75 S93 C120 Y168
BS02 4IS C M174 W177 W178 M172 W175 W176
BS03 4IS C F215 D233 F213 D231
BS04 NDP C A232 M237 A230 M235
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
Biological Process
GO:0016054 organic acid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7y8l, PDBe:7y8l, PDBj:7y8l
PDBsum7y8l
PubMed
UniProtE2PUR9

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