Structure of PDB 7y0b Chain C

Receptor sequence
>7y0bC (length=387) Species: 9606 (Homo sapiens) [Search protein sequence]
LHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHLFPAAQVKKM
GGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYL
GPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEG
DSWVLNGTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTL
GKKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIG
IASQALGIAQTALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESA
RLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQILGGMGYVT
EMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYR
3D structure
PDB7y0b Crystal structure of human short-chain acyl-coA dehydrogenase
ChainC
Resolution2.076 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.3.8.1: short-chain acyl-CoA dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C L154 S155 G160 S161 W185 T187 I387 T394 E396 L400 L130 S131 G136 S137 W161 T163 I363 T370 E372 L376
BS02 FAD C R297 F300 L304 L307 Q365 I366 G369 R273 F276 L280 L283 Q341 I342 G345
Gene Ontology
Molecular Function
GO:0003995 acyl-CoA dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0016937 short-chain fatty acyl-CoA dehydrogenase activity
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0046359 butyrate catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005813 centrosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7y0b, PDBe:7y0b, PDBj:7y0b
PDBsum7y0b
PubMed
UniProtP16219|ACADS_HUMAN Short-chain specific acyl-CoA dehydrogenase, mitochondrial (Gene Name=ACADS)

[Back to BioLiP]