Structure of PDB 7xxr Chain C

Receptor sequence

>7xxrC (length=482) Species: 285500 (Streptomyces luteocolor)

QTDVIVVGNGVLGLSVGVEIARTRPDVRVTLLGKPARQYGATPAAGAMLG
AFGEVTAHALASEHGRKKHALAVQAQRLWPEWIESLEATGTAADGRIKTA
DDTVVLLNTVGHSALDDANFAAVLTALKEANAPHEEIAVESVDWIDPDPN
SRPLRALHIEGEGSVDSGILLAALERSFLQAGGRLHPVDATEIRASHGRV
EGVVTDDGDFLPAGHVVVAAGARSQRLVAALPGLAHRIPRIYDGVGVSAL
VDTWDGSGPATVLRTSNRAFACGLHLVPRAGGSVYIGATNAVCLEPRGAA
SIEETVFLFNCATHQLHRGLNGSELRKVQVGSAPAPIDGFPLIGGTSVEG
LWMLSGTYRDGLHMSPLLARHVVSLMDGGTGVDGLREFRPERDLISAWSR
EEILDDVVRHTMATGYEFPWRLPLEWPHMMETFLQGPFAELADRLSDTYT
PPADLMTAIMFSEREQQDELIAYYADVHREWH

3D structure

• PDB: 7xxr N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry.
• Chain: C
• Resolution: 2.4 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	I55	C	E434 M438	E425 M429
BS02	FAD	C	V16 N18 G19 L21 R46 Q47 A50 T51 A54 M57 D198 A199 G230 R232 G255 G340 T366 Y367 R368 D369 G370 L371	V7 N9 G10 L12 R37 Q38 A41 T42 A45 M48 D189 A190 G221 R223 G246 G331 T357 Y358 R359 D360 G361 L362
BS03	I55	C	N299 R306 S310 E312 T423 T466 F470	N290 R297 S301 E303 T414 T457 F461

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7xxr, PDBe:7xxr, PDBj:7xxr
• PDBsum: 7xxr
• PubMed: 37137912
• UniProt: A0A125SZC1