Structure of PDB 7xoh Chain C

Receptor sequence
>7xohC (length=458) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
IAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVKMI
EAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDK
RNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPE
GPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVR
IVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSF
DMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRGYM
SKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVHTHPSET
VRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKL
ADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYD
LLGFLSEG
3D structure
PDB7xoh S-Adenosylmethionine-responsive cystathionine beta-synthase modulates sulfur metabolism and redox balance in Mycobacterium tuberculosis.
ChainC
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.1.22: cystathionine beta-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP C K44 N74 T182 S269 D296 K42 N72 T180 S267 D294
Gene Ontology
Molecular Function
GO:0004122 cystathionine beta-synthase activity
GO:0004124 cysteine synthase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006534 cysteine metabolic process
GO:0006535 cysteine biosynthetic process from serine
GO:0009069 serine family amino acid metabolic process
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0044272 sulfur compound biosynthetic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xoh, PDBe:7xoh, PDBj:7xoh
PDBsum7xoh
PubMed35749503
UniProtP9WP51|Y1077_MYCTU Probable cystathionine beta-synthase Rv1077 (Gene Name=cbs)

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