Structure of PDB 7xbk Chain C

Receptor sequence

>7xbkC (length=349) Species: 9606 (Homo sapiens)

KEAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFL
FLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPP
GYVGHEEGGQLTKKLKQCPNAVVLFDQVDKAHPDVLTIMLQLFDEGRLTD
GKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDV
QISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQ
LVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVER
RVVNQLAAAYEQDLLPGGCTLRITVEDSDKLLPKLRLEIIDKDSKTRRL

3D structure

• PDB: 7xbk Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization.
• Chain: C
• Resolution: 3.7 Å

Enzymatic activity

• Enzyme Commision number: 3.6.1.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	G399 Y400 V401	G101 Y102 V103
BS02	ATP	C	I317 I318 S353 G354 I355 G356 K357 T358 E359 Q425 L549 A589 R590 K593	I19 I20 S55 G56 I57 G58 K59 T60 E61 Q127 L251 A291 R292 K295

Gene Ontology

Molecular Function

• GO:0003674 molecular_function
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0140545 ATP-dependent protein disaggregase activity

Biological Process

• GO:0030851 granulocyte differentiation
• GO:0034605 cellular response to heat
• GO:0039529 RIG-I signaling pathway
• GO:0140374 antiviral innate immune response

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space

External links

• PDB: RCSB:7xbk, PDBe:7xbk, PDBj:7xbk
• PDBsum: 7xbk
• PubMed: 36745679
• UniProt: Q9H078|CLPB_HUMAN Mitochondrial disaggregase (Gene Name=CLPB)