Structure of PDB 7x8b Chain C

Receptor sequence
>7x8bC (length=148) Species: 9606 (Homo sapiens) [Search protein sequence]
NQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVV
FWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTY
DLFLNLEGNPPVNHLNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEG
3D structure
PDB7x8b Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer.
ChainC
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R121 E123 R119 E121
BS02 peptide C H56 S58 F59 G77 Y78 A79 G80 F81 D103 L106 N107 H54 S56 F57 G75 Y76 A77 G78 F79 D101 L104 N105
Gene Ontology
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Biological Process
External links
PDB RCSB:7x8b, PDBe:7x8b, PDBj:7x8b
PDBsum7x8b
PubMed36272410
UniProtQ03111|ENL_HUMAN Protein ENL (Gene Name=MLLT1)

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