Structure of PDB 7x6c Chain C

Receptor sequence

>7x6cC (length=675) Species: 9606 (Homo sapiens)

RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECV
SSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSK
VENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVAI
KYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPML
SIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLH
VQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNS
LYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLI
SLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYET
RAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARH
EFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFART
KLWMSYFDEGGTLPPPFNIIPDSLIQNQHYQEVIRNLVKRYVAAMIRNSK
THEGLTEENFKELKQDISSFRYEVL

3D structure

• PDB: 7x6c Molecular architecture of the G alpha i -bound TRPC5 ion channel.
• Chain: C
• Resolution: 3.15 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	C	Y316 F364 A499	Y272 F320 A455
BS02	ZN	C	H172 C176 C181	H140 C144 C149
BS03	CA	C	E418 N436 D439	E374 N392 D395
BS04	YZY	C	F599 T603 T607	F555 T559 T563
BS05	YZY	C	L514 Y524 F576	L470 Y480 F532

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005262 calcium channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7x6c, PDBe:7x6c, PDBj:7x6c
• PDBsum: 7x6c
• PubMed: 37137991
• UniProt: Q9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)