Structure of PDB 7wrr Chain C

Receptor sequence

>7wrrC (length=650) Species: 300852 (Thermus thermophilus HB8)

KETRDLETLSVNAIRFLAIDAVEKARSGHPGMPMGMAPLAYLLFREVMRH
NPLDPDWPDRDRFVLSAGHGSMLLYAVLHLTGYDLPLEELKSFRQWGSKT
PGHPERGHTPGVEVTTGPLGQGISTAVGLALAERKLAAEFNRPGHVVVDH
YTYVLASDGDLMEGVSGEAASLAGHWGLSKLIVFWDDNRISIDGPTDLAF
TEDVLARYRAYGWQTLRVEDVNDLEALRKAIKLAKLDERPTLIAVRSHIG
FGSPKQDSAKAHGEPLGPEAVEATRRNLGWPYPPFVVPEEVYRHMDMREK
GRAWQEAWEKALEAYARAYPDLHQELMRRLRGELPPLPEEPPSFDKPIAT
RAASGRALNLLAPRLPELLGGSADLTPSNNTKAEGMEDFSRANPLGRYLH
FGVREHAMGAILNGLNLHGGYRAYGGTFLVFSDYMRPAIRLAALMGVPTV
FVFTHDSIALGEDGPTHQPVEHLMSLRAMPNLFVIRPADAYETFYAWLVA
LRRKEGPTALVLTRQAVPLLSPEKARGLLRGGYVLEDVEEPQGVLVATGS
EVHLALRAQALLREKGVRVRVVSLPSFELFAAQPEAYRKEVLPPGLPVVA
VEAGASLGWERYAHKVVALDRFGASAPYPEVYERLGFTPERVAEAFLSLV

3D structure

• PDB: 7wrr Structural and biochemical characterizations of Thermus thermophilus HB8 transketolase producing a heptulose.
• Chain: C
• Resolution: 2.01 Å

Enzymatic activity

• Enzyme Commision number: 2.2.1.1: transketolase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	TPP	C	H70 L120 S158 D159 G160 N189 I191 I193 H263	H69 L119 S157 D158 G159 N188 I190 I192 H262
BS02	CA	C	D159 N189 I191	D158 N188 I190
BS03	TPP	C	D375 E406 F432 Y435	D374 E405 F431 Y434

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004802 transketolase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006098 pentose-phosphate shunt

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7wrr, PDBe:7wrr, PDBj:7wrr
• PDBsum: 7wrr
• PubMed: 36441206
• UniProt: Q5SM35