Structure of PDB 7wrc Chain C

Receptor sequence
>7wrcC (length=930) Species: 10090 (Mus musculus) [Search protein sequence]
AFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFAL
KPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEE
NIVAIGIAAWGMVSNRDTLIDEGHFSAYILDNNHTHLLLVDNGCHGHPTV
EAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSK
IPCVVVEGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIK
WLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQ
LKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLE
NGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVA
NFRRRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAK
VKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGG
SNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIP
LVGCGLVSFRKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDF
HSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFI
AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIML
QRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLA
MFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLN
IPFPFVVFAYFYMVVKKCFKFRNEDNETLAWEGVMKENYLVKINTKANDN
SEEMRHRFRQLDSKLNDLKSLLKEIANNIK
3D structure
PDB7wrc Structures of a mammalian TRPM8 in closed state.
ChainC
Resolution3.21 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C E782 Q785 N799 D802 R842 E622 Q625 N639 D642 R682
BS02 KX7 C N741 L778 D802 L806 F839 R842 I846 N581 L618 D642 L646 F679 R682 I686
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7wrc, PDBe:7wrc, PDBj:7wrc
PDBsum7wrc
PubMed35662242
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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