Structure of PDB 7whu Chain C

Receptor sequence
>7whuC (length=218) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRA
VRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATI
NANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTS
LCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYP
DAFAPVAQFVNWIDSIIQ
3D structure
PDB7whu Sequence preference and scaffolding requirement for the inhibition of human neutrophil elastase by ecotin peptide
ChainC
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.37: leukocyte elastase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V176 F178 S181 A195 S196 F197 V198 R199A V168 F170 S173 A187 S188 F189 V190 R191
BS02 FUC C Q131 N188 Q121 N180
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7whu, PDBe:7whu, PDBj:7whu
PDBsum7whu
PubMed
UniProtP08246|ELNE_HUMAN Neutrophil elastase (Gene Name=ELANE)

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