Structure of PDB 7w6a Chain C

Receptor sequence

>7w6aC (length=159) Species: 9606 (Homo sapiens) [Search protein sequence]

SDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGI
VIRSILTDKREKYYDSKGIGSSYMFRIDDSEVVDATMHGNAARFINHSCE
PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG
AKKCRKFLN

3D structure

PDB

7w6a Structural basis for product specificities of MLL family methyltransferases.

Chain

Resolution

2.21 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.1.1.-
2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	C	R3821 K3824 E3857 A3859 G3860 I3861 V3862 R3864 I3866 L3867 K3870 R3871 M3898 H3899 G3900 N3901 Q3924	R10 K13 E46 A48 G49 I50 V51 R53 I55 L56 K59 R60 M87 H88 G89 N90 Q113
BS02	SAH	C	I3838 H3839 G3840 R3841 Y3884 N3907 H3908 Y3945 L3956 C3958 N3959	I27 H28 G29 R30 Y73 N96 H97 Y134 L145 C147 N148
BS03	ZN	C	C3910 C3958 C3960 C3965	C99 C147 C149 C154

External links

PDB	RCSB:7w6a, PDBe:7w6a, PDBj:7w6a
PDBsum	7w6a
PubMed	36108631
UniProt	Q03164\|KMT2A_HUMAN Histone-lysine N-methyltransferase 2A (Gene Name=KMT2A)

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