Structure of PDB 7w5a Chain C

Receptor sequence
>7w5aC (length=862) Species: 9606 (Homo sapiens) [Search protein sequence]
EVVLHEDKKYYPTAEEVYGPEVETIVQEEDTQPLTEPIIKPVKTTVYEMD
FLADLMDNSELIRNVTLCGHLHHGKTCFVDCLIEQTHPEIRTEQERGVGI
KSTPVTVVLPDTKGKSYLFNIMDTPGHVNFSDEVTAGLRISDGVVLFIDA
AEGVMLNTERLIKHAVQERLAVTVCINKIDRLILELKLPPTDAYYKLRHI
VDEVNGLISMYSTDENLILSPLLGNVCFSSSQYSICFTLGSFAKIYADTF
GDINYQEFAKRLWGDIYFNPKTRKFTKKAPTSSSQRSFVEFILEPLYKIL
AQVVGDVDTSLPRTLDELGIHLTKEELKLNIRPLLRLVCKKFFGEFTGFV
DMCVQHIPSPKVGAKPKIEHTYTGGVDSDLGEAMSDCDPDGPLMCHTTKM
YSTDDGVQFHAFGRVLSGTIHAGQPVKVLGENYTLEDEEDSQICTVGRLW
ISVARYHIEVNRVPAGNWVLIEGVDQPIVKTATITEPRGNEEAQIFRPLK
FNTTSVIKIAVEPVNPSELPKMLDGLRKVNKSYPSLTTKVEESGEHVILG
TGELYLDCVMHDLRKMYSEIDIKVADPVVTFCETVVETSSLKCFAETPNK
KNKITMIAEPLEKGLAEDIENEVVQITWNRKKLGEFFQTKYDWDLLAARS
IWAFGPDATGPNILVDDTLPSEVDKALLGSVKDSIVQGFQWGTREGPLCD
ELIRNVKFKILDAVVAQEPLHRGGGQIIPTARRVVYSAFLMATPRLMEPY
YFVEVQAPADCVSAVYTVLARRRGHVTQDAPIPGSPLYTIKAFIPAIDSF
GFETDLRTHTQGQAFSLSVFHHWQIVPGDPLDKSIVIRPLEPQPAPHLAR
EFMIKTRRRKGL
3D structure
PDB7w5a Mechanism of exon ligation by human spliceosome.
ChainC
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C R852 H890 R771 H809
BS02 GTP C H139 G141 K142 T143 G180 K259 D261 S311 S312 Q313 H72 G74 K75 T76 G99 K178 D180 S230 S231 Q232
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0030623 U5 snRNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0042220 response to cocaine
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0015030 Cajal body
GO:0016020 membrane
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071005 U2-type precatalytic spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w5a, PDBe:7w5a, PDBj:7w5a
PDBsum7w5a
PubMed35705093
UniProtQ15029|U5S1_HUMAN 116 kDa U5 small nuclear ribonucleoprotein component (Gene Name=EFTUD2)

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