Structure of PDB 7w3i Chain C

Receptor sequence
>7w3iC (length=386) Species: 9606 (Homo sapiens) [Search protein sequence]
EEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLRE
ELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPN
CRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEI
KEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTF
IRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEG
GSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRI
DRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKG
VCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEK
3D structure
PDB7w3i USP14-regulated allostery of the human proteasome by time-resolved cryo-EM.
ChainC
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP C I151 P192 G193 T194 G195 K196 T197 L198 I328 H332 A357 I140 P181 G182 T183 G184 K185 T186 L187 I317 H321 A346
Gene Ontology
Molecular Function
GO:0005102 signaling receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008134 transcription factor binding
GO:0016887 ATP hydrolysis activity
GO:0031531 thyrotropin-releasing hormone receptor binding
GO:0036402 proteasome-activating activity
GO:0140296 general transcription initiation factor binding
GO:0140297 DNA-binding transcription factor binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0043069 negative regulation of programmed cell death
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045892 negative regulation of DNA-templated transcription
GO:0045893 positive regulation of DNA-templated transcription
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005838 proteasome regulatory particle
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0022624 proteasome accessory complex
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7w3i, PDBe:7w3i, PDBj:7w3i
PDBsum7w3i
PubMed35477760
UniProtP62195|PRS8_HUMAN 26S proteasome regulatory subunit 8 (Gene Name=PSMC5)

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