Structure of PDB 7w1y Chain C

Receptor sequence
>7w1yC (length=651) Species: 9606 (Homo sapiens) [Search protein sequence]
VRGTPVRQRPDLGSAQKGLQVDLQSKLVIWGTDVNVAACKENFQRFLQRF
IDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLY
RQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRN
LNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIA
EPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILF
AHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRK
TDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEH
EDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYV
YNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCI
DEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQ
WNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQL
DMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPR
QLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVD
I
3D structure
PDB7w1y The human pre-replication complex is an open complex.
ChainC
Resolution2.59 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C R404 S539 V541 R281 S416 V418
BS02 dna C K549 L556 K426 L433
BS03 ZN C C306 C309 C328 C331 C183 C186 C205 C208
BS04 ATP C I470 Y471 P512 G513 S515 K516 S517 Q518 N618 L662 I347 Y348 P389 G390 S392 K393 S394 Q395 N495 L539
BS05 ADP C R497 P731 R732 E735 R374 P599 R600 E603
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
Biological Process
GO:0000727 double-strand break repair via break-induced replication
GO:0006139 nucleobase-containing compound metabolic process
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006270 DNA replication initiation
GO:0006271 DNA strand elongation involved in DNA replication
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0032508 DNA duplex unwinding
GO:1902975 mitotic DNA replication initiation
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0016020 membrane
GO:0042555 MCM complex
GO:0071162 CMG complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7w1y, PDBe:7w1y, PDBj:7w1y
PDBsum7w1y
PubMed36608662
UniProtP33991|MCM4_HUMAN DNA replication licensing factor MCM4 (Gene Name=MCM4)

[Back to BioLiP]