Structure of PDB 7va1 Chain C

Receptor sequence
>7va1C (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLSAAELTCGMIMCLARQIPQATASMKDGKWERKKFMGTELNGKTLGIL
GLGRIGREVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEIWPLCD
FITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCARGGIVDEGALLRALQS
GQCAGAALDVFTEEPPRDRALVDHENVISCPHLGASTKEAQS
3D structure
PDB7va1 Crystal structure of human 3-phosphoglycerate dehydrogenase in complex with GDD-04-35
ChainC
Resolution1.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.37: malate dehydrogenase.
1.1.1.399: 2-oxoglutarate reductase.
1.1.1.95: phosphoglycerate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5YP C L151 R158 Y174 D175 P176 I177 I178 V182 T207 P208 L210 L216 L50 R57 Y73 D74 P75 I76 I77 V81 T106 P107 L109 L115
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:7va1, PDBe:7va1, PDBj:7va1
PDBsum7va1
PubMed
UniProtO43175|SERA_HUMAN D-3-phosphoglycerate dehydrogenase (Gene Name=PHGDH)

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