Structure of PDB 7v0r Chain C

Receptor sequence

>7v0rC (length=340) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKPLSHFVLSAT
KMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIIL
ALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETWRLS
FSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELD
AFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLD
HYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

7v0r Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -ppcpG(2 ,5 )pA

Chain

Resolution

2.51 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T174 K175 T178
BS02	dna	C	R222 K315	R74 K155
BS03	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H55 K229
BS04	dna	C	R161 S165 A168 Y200 K372	R13 S17 A20 Y52 K206
BS05	OKX	C	G198 S199 E211 D213 P292 D307 I309 K350 R364 S366 S368 K402 C419 S420 Y421	G50 S51 E63 D65 P132 D147 I149 K190 R198 S200 S202 K236 C253 S254 Y255
BS06	MG	C	E211 D213	E63 D65
BS07	MG	C	E211 D213 D307	E63 D65 D147
BS08	ZN	C	H378 C384 C385 C392	H212 C218 C219 C226

External links

PDB	RCSB:7v0r, PDBe:7v0r, PDBj:7v0r
PDBsum	7v0r
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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