Structure of PDB 7v0e Chain C

Receptor sequence
>7v0eC (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
ARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAVGTVKHE
GNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCKGLYEGTGRLFFEFYHLL
NYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVMIDAIKVSAA
HRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSN
SIKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKL
LGRSWSVPVIRHLFAPLKDYFACE
3D structure
PDB7v0e Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations.
ChainC
Resolution3.27016 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C F581 G583 T586 E605 V606 D627 V628 L671 R832 S833 W834 F12 G14 T17 E36 V37 D58 V59 L92 R253 S254 W255
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7v0e, PDBe:7v0e, PDBj:7v0e
PDBsum7v0e
PubMed35869095
UniProtQ9UBC3|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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