Structure of PDB 7uzr Chain C

Receptor sequence

>7uzrC (length=341) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFSHFLVLSAT
KMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIIL
ALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKQGETWRL
SFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQEL
DAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKL
DHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK

3D structure

PDB

7uzr Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T174 K175 T178
BS02	dna	C	R222 K315	R74 K155
BS03	dna	C	R158 L159 K160 R161 K184 H203 K395	R10 L11 K12 R13 K36 H55 K230
BS04	dna	C	R161 S165 Y200 K372	R13 S17 Y52 K207
BS05	OKR	C	G198 S199 E211 D213 R364 K402 C419 S420 Y421	G50 S51 E63 D65 R199 K237 C254 S255 Y256
BS06	ZN	C	H378 C384 C385 C392	H213 C219 C220 C227
BS07	MN	C	E211 D213 D307	E63 D65 D147
BS08	MN	C	E211 D213	E63 D65

External links

PDB	RCSB:7uzr, PDBe:7uzr, PDBj:7uzr
PDBsum	7uzr
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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