Structure of PDB 7uyq Chain C

Receptor sequence

>7uyqC (length=339) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKEFKGVEQLNTGSYY
EHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLSATKM
LSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILAL
ESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGETWRLSFS
HTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAF
CSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHY
FIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

7uyq Structure of GTP binds to Cyclic GMP AMP synthase (cGAS) through Mg coordination

Chain

Resolution

2.57 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T172 K173 T176
BS02	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H52 K227
BS03	dna	C	R161 S165 A168 N196 Y200 Y201 K372	R13 S17 A20 N45 Y49 Y50 K204
BS04	GTP	C	M215 S291 D307 I309 K350 R364 S366 S368	M64 S129 D145 I147 K188 R196 S198 S200
BS05	GTP	C	G198 S199 Q211 N213 R364 S368 E371 K402 S420 Y421	G47 S48 Q60 N62 R196 S200 E203 K234 S252 Y253
BS06	MG	C	Q211 N213	Q60 N62
BS07	ZN	C	H378 C384 C385 C392	H210 C216 C217 C224

External links

PDB	RCSB:7uyq, PDBe:7uyq, PDBj:7uyq
PDBsum	7uyq
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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