Structure of PDB 7uxw Chain C

Receptor sequence

>7uxwC (length=345) Species: 10090 (Mus musculus) [Search protein sequence]

KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNQFNVMFKLEVPRIELQEYYETGAFYLVKFNPLSHFLGV
LSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISV
DIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQGET
WRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEF
QELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRT
EKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL

3D structure

PDB

7uxw ATP and GTP bind to Cyclic GMP AMP synthase (cGAS) through Mg coordination

Chain

Resolution

2.57 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.7.86: cyclic GMP-AMP synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	C	T334 K335 T338	T178 K179 T182
BS02	dna	C	R158 L159 K160 R161 H203 K395	R10 L11 K12 R13 H55 K233
BS03	dna	C	R161 S165 A168 N196 Y200 Y201 K372	R13 S17 A20 N48 Y52 Y53 K210
BS04	ATP	C	G198 S199 Q211 N213 R364 S368 E371 K402 S420 Y421	G50 S51 Q63 N65 R202 S206 E209 K240 S258 Y259
BS05	GTP	C	T197 N213 M215 S291 D307 I309 K350 R364 S366 S368	T49 N65 M67 S135 D151 I153 K194 R202 S204 S206
BS06	MG	C	Q211 N213	Q63 N65
BS07	ZN	C	H378 C384 C385 C392	H216 C222 C223 C230

External links

PDB	RCSB:7uxw, PDBe:7uxw, PDBj:7uxw
PDBsum	7uxw
PubMed
UniProt	Q8C6L5\|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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