Structure of PDB 7uwh Chain C

Receptor sequence
>7uwhC (length=190) Species: 562 (Escherichia coli) [Search protein sequence]
TQLVAGVDAVGRGPLVGAVVTAAVILDPARPIAGLNDSKKLSEKRRLALY
EEIKEKALSWSLGRAEPHEIDELNILHATMLAMQRAVAGLHIAPEYVLID
GNRCPKLPMPAMAVVKGDSRVPEISAASILAKVTRDAEMAALDIVFPQYG
FAQHKGYPTAFHLEKLAEHGATEHHRRSFGPVKRALGLAS
3D structure
PDB7uwh RNA polymerase drives ribonucleotide excision DNA repair in E. coli.
ChainC
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C N82 L84 P166 F187 G188 P189 N74 L76 P158 F179 G180 P181
BS02 dna C D16 A17 V18 G19 R20 D108 K124 H162 Y165 P166 D8 A9 V10 G11 R12 D100 K116 H154 Y157 P158
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006298 mismatch repair
GO:0006401 RNA catabolic process
GO:0043137 DNA replication, removal of RNA primer
GO:1990516 ribonucleotide excision repair
Cellular Component
GO:0005737 cytoplasm
GO:0032299 ribonuclease H2 complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7uwh, PDBe:7uwh, PDBj:7uwh
PDBsum7uwh
PubMed37196657
UniProtP10442|RNH2_ECOLI Ribonuclease HII (Gene Name=rnhB)

[Back to BioLiP]