Structure of PDB 7usl Chain C

Receptor sequence

>7uslC (length=715) Species: 520 (Bordetella pertussis)

DGLRKMLADLQAGWNASSVIGVQTTEISKSALELAAITGNADNLKSVDVF
VDRFVQGERVVLDVAAGGIDIASRKGERPALTFITPLAAPGEEQRRRTKT
GKSEFTTFVEIVGKQDRWRIRDGAADTTIDLAKVVSQLVDANGVLKHSIK
LDVIGGDGDDVVLANASRIHYDGGAGTNTVSYAALGRQDSITVSADGERF
NVRKQLNNANVYREGVATQTTAYGKRTENVQYRHVELARVGQLVEVDTLE
HVQHIIGGAGNDSITGNAHDNFLAGGSGDDRLDGGAGNDTLVGGEGQNTV
IGGAGDDVFLQDLGVWSNQLDGGAGVDTVKYNVHQPSEERLERMGDTGIH
ADLQKGTVEKWPALNLFSVDHVKNIENLHGSRLNDRIAGDDQDNELWGHD
GNDTIRGRGGDDILRGGLGLDTLYGEDGNDIFLQDDETVSDDIDGGAGLD
TVDYSAMIHPGRIVAPHEYGFGIEADLSREWVRKASALGVDYYDNVRNVE
NVIGTSMKDVLIGDAQANTLMGQGGDDTVRGGDGDDLLFGGDGNDMLYGD
AGNDTLYGGLGDDTLEGGAGNDWFGQTQAREHDVLRGGDGVDTVDYLGIL
ADLGAGRVDKLGEAGSSAYDTVSGIENVVGTELADRITGDAQANVLRGAG
GADVLAGGEGDDVLLGGDGDDQLSGDAGRDRLYGEAGDDWFFQDAANAGN
LLDGGDGRDTVDFSG

3D structure

• PDB: 7usl Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin.
• Chain: C
• Resolution: 2.7 Å

Enzymatic activity

• Enzyme Commision number: 4.6.1.1: adenylate cyclase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	D880 A883 G913 D915 D918	D122 A125 G155 D157 D160
BS02	CA	C	G916 D918 G931 A933 N936	G158 D160 G173 A175 N178
BS03	CA	C	G1016 G1018 D1020 G1033 S1035 D1038	G258 G260 D262 G275 S277 D280
BS04	CA	C	N1025 H1027 N1029 G1042 A1044 D1047	N267 H269 N271 G284 A286 D289
BS05	CA	C	G1034 G1036 D1038 G1051 G1052 E1053 N1056	G276 G278 D280 G293 G294 E295 N298
BS06	CA	C	G1043 A1044 G1045 D1047 G1060 G1061 A1062 D1065	G285 A286 G287 D289 G302 G303 A304 D307
BS07	CA	C	G1061 A1062 G1063 D1065 G1080 G1081 A1082 D1085	G303 A304 G305 D307 G322 G323 A324 D327
BS08	CA	C	G1081 G1083 D1085 N1132 E1134	G323 G325 D327 N374 E376
BS09	CA	C	S1139 L1141 D1143 G1156 D1158 D1161	S381 L383 D385 G398 D400 D403
BS10	CA	C	D1148 Q1150 N1152 G1165 G1167 D1170	D390 Q392 N394 G407 G409 D412
BS11	CA	C	H1157 G1159 D1161 G1174 G1175 L1176 D1179	H399 G401 D403 G416 G417 L418 D421
BS12	CA	C	R1166 G1167 G1168 D1170 G1183 D1185 D1188	R408 G409 G410 D412 G425 D427 D430
BS13	CA	C	G1175 G1177 D1179 E1195 D1199	G417 G419 D421 E437 D441
BS14	CA	C	E1184 G1186 D1188 G1203 A1205 D1208	E426 G428 D430 G445 A447 D450
BS15	CA	C	G1204 G1206 D1208 N1256 E1258	G446 G448 D450 N498 E500
BS16	CA	C	T1263 M1265 D1267 G1280 G1282 D1285	T505 M507 D509 G522 G524 D527
BS17	CA	C	D1272 Q1274 N1276 G1289 D1291 D1294	D514 Q516 N518 G531 D533 D536
BS18	CA	C	Q1281 G1282 G1283 D1285 G1298 G1299 D1300 D1303	Q523 G524 G525 D527 G540 G541 D542 D545
BS19	CA	C	G1290 G1292 D1294 G1307 A1309 D1312	G532 G534 D536 G549 A551 D554
BS20	CA	C	G1299 G1301 D1303 G1316 L1318 D1321	G541 G543 D545 G558 L560 D563
BS21	CA	C	D1308 G1310 D1312 G1325 A1327 D1330	D550 G552 D554 G567 A569 D572
BS22	CA	C	G1317 G1319 D1321 E1339 D1341	G559 G561 D563 E581 D583
BS23	CA	C	G1345 G1346 G1348 D1350 G1397 E1399	G587 G588 G590 D592 G624 E626
BS24	CA	C	T1404 L1406 D1408 G1421 A1422 G1423 D1426	T631 L633 D635 G648 A649 G650 D653
BS25	CA	C	D1413 Q1415 N1417 G1430 E1432 D1435	D640 Q642 N644 G657 E659 D662
BS26	CA	C	A1422 G1423 G1424 D1426 G1439 D1441 D1444	A649 G650 G651 D653 G666 D668 D671
BS27	CA	C	G1430 G1431 E1432 G1433 D1435 A1450 D1453	G657 G658 E659 G660 D662 A677 D680
BS28	CA	C	G1440 G1442 D1444 G1457 E1458 A1459 D1462	G667 G669 D671 G684 E685 A686 D689
BS29	CA	C	E1458 A1459 G1460 D1462 G1477 D1479 D1482	E685 A686 G687 D689 G704 D706 D709

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0015267 channel activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:7usl, PDBe:7usl, PDBj:7usl
• PDBsum: 7usl
• PubMed: 35977491
• UniProt: P0DKX7|CYAA_BORPE Bifunctional hemolysin/adenylate cyclase (Gene Name=cya)