Structure of PDB 7ujo Chain C

Receptor sequence
>7ujoC (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
SLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLS
STLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSMKSKNVVPSYDLLLEMLDA
3D structure
PDB7ujo Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
ChainC
Resolution1.449 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 QYM C T347 A350 D351 E353 W383 E419 G420 M421 I424 V533 T39 A42 D43 E45 W75 E106 G107 M108 I111 V220
External links
PDB RCSB:7ujo, PDBe:7ujo, PDBj:7ujo
PDBsum7ujo
PubMed35575456
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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