Structure of PDB 7uhy Chain C

Receptor sequence
>7uhyC (length=578) Species: 9606 (Homo sapiens) [Search protein sequence]
VLTGRTMHCHLDAPANAISVCRDAAQVVVAGRSIFKIYAIEEEQFVEKLN
LRVGRKPSLNLSCADVVWHQMDENLLATAATNGVVVTWNLGRPSRNKQDQ
LFTEHKRTVNKVCFHPTEAHVLLSGSQDGFMKCFDLRRKDSVSTFSGQSE
SVRDVQFSIRDYFTFASTFENGNVQLWDIRRPDRCERMFTAHNGPVFCCD
WHPEDRGWLATGGRDKMVKVWDMTTHRAKEMHCVQTIASVARVKWRPECR
HHLATCSMMVDHNIYVWDVRRPFVPAAMFEEHRDVTTGIAWRHPHDPSFL
LSGSKDSSLCQHLFRDASQPVERANPEGLCYGLFGDLAFAAKESLVAFAG
LASSALSVFETEGMRWFVDTAERYALAGRPLAELCDHNAKVARELGRNQV
AQTWTMLRIIYCSSRLPPDFFGVLVRDMLHFYAEQGDVQMAVSVLIVLGE
RVRKDIDEQTQEHWYTSYIDLLQRFRLWNVSNEVVKLSTSRAVSCLNQAS
TTLHVNCSHCKRPMSSRGWVCDRCHRCASMCAVCHHVVKGLFVWCQGCSH
GGHLQHIMKWLEGSSHCPAGCGHLCEYS
3D structure
PDB7uhy Structure of the nutrient-sensing hub GATOR2.
ChainC
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C719 C722 C733 C736 C507 C510 C521 C524
BS02 ZN C C743 C746 H765 H768 C531 C534 H553 H556
BS03 ZN C C757 C760 H785 C787 C545 C548 H573 C575
BS04 ZN C C760 H762 C779 C783 C548 H550 C567 C571
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0006914 autophagy
GO:0010506 regulation of autophagy
GO:0016239 positive regulation of macroautophagy
GO:0016567 protein ubiquitination
GO:0031669 cellular response to nutrient levels
GO:0032008 positive regulation of TOR signaling
GO:0034198 cellular response to amino acid starvation
GO:0085020 protein K6-linked ubiquitination
GO:1904262 negative regulation of TORC1 signaling
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0061700 GATOR2 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7uhy, PDBe:7uhy, PDBj:7uhy
PDBsum7uhy
PubMed35831510
UniProtQ96S15|WDR24_HUMAN GATOR2 complex protein WDR24 (Gene Name=WDR24)

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