Structure of PDB 7uh8 Chain C

Receptor sequence

>7uh8C (length=453) Species: 9606 (Homo sapiens)

LNLDPVQLTFYAGPNGSQFGFSLDFHKDSHGRVAIVVGAPRTLGPSQEET
GGVFLCPWRAEGGQCPSLLFDLRDETRNVGSQTLQTFKARQGLGASVVSW
SDVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNT
LSRIYVENDFSWDKRYCEAGFSSVVTQAGELVLGAPGGYYFLGLLAQAPV
ADIFSSYRPGILLWHVSSQSLSFDSSNPEYFDGYWGYSVAVGEFDGDLNT
TEYVVGAPTWSWTLGAVEILDSYYQRLHRLRGEQMASYFGHSVAVTDVNG
DGRHDLLVGAPLYMESRADRKLAEVGRVYLFLQPRGPHALGAPSLLLTGT
QLYGRFGSAIAPLGDLDRDGYNDIAVAAPYGGPSGRGQVLVFLGQSEGLR
SRPSQVLDSPFPTGSAFGFSLRGAVDIDDNGYPDLIVGAYGANQVAVYRA
QPV

3D structure

• PDB: 7uh8 A general chemical principle for creating closure-stabilizing integrin inhibitors.
• Chain: C
• Resolution: 2.75002 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	C	E243 D245 D247 T250 T251 E252	E243 D245 D247 T250 T251 E252
BS02	CA	C	D297 N299 D301 R303 D305	D297 N299 D301 R303 D305
BS03	CA	C	D365 D367 D369 Y371 D373	D365 D367 D369 Y371 D373
BS04	CA	C	D426 D428 N430 Y432 D434	D426 D428 N430 Y432 D434
BS05	N9U	C	F160 Y190 L192 D224 S225 F231	F160 Y190 L192 D224 S225 F231

Gene Ontology

Biological Process

• GO:0007155 cell adhesion

Cellular Component

• GO:0008305 integrin complex

External links

• PDB: RCSB:7uh8, PDBe:7uh8, PDBj:7uh8
• PDBsum: 7uh8
• PubMed: 36113427
• UniProt: P08514|ITA2B_HUMAN Integrin alpha-IIb (Gene Name=ITGA2B)