Structure of PDB 7tu7 Chain C

Receptor sequence
>7tu7C (length=431) Species: 398720 (Leeuwenhoekiella blandensis MED217) [Search protein sequence]
NWEHLLSLKRQGDTAKRLRIEQLGFEVDYDRIIFSAPFRSLQDKTQVIPL
SKTDFVHTRLTHSLEVSVVGRSLGRMVGKKLLEKYPHLEQVYGYKFNDFG
AIVAAAALAHDIGNPPFGASGEKAIGEFFKNGYGKRYKDSLTAKEYQDLI
KFEGNANGFKVLSQSKPGAQGGLRLSYATLGAFMKYPKESLPHKPSDHIA
DKKYGFFQSERALFEDVAQELGLLKRSTTDDVSWSRHPLAYLVEAADDIC
YTIIDFEDGINLGLIPEEYALEYMVKLVGQTIDRNKYNALQETSDRVSYL
RALAIGTLINESVDTFMKYEEEILAGTFDQSLIDKSNYQAQITDIINLSI
ERIYNSREVIEKEIAGYEILSTLLEARCRALDNNDTHYNQLIQQLLAPEK
SLYENLIQICAEVSTMTDGKALRNYKKIKGL
3D structure
PDB7tu7 High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.5.1: dGTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DGT C Q52 V53 K191 D253 D261 Q46 V47 K185 D247 D255
BS02 MG C H68 H116 D117 D253 H62 H110 D111 D247
Gene Ontology
Molecular Function
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006203 dGTP catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7tu7, PDBe:7tu7, PDBj:7tu7
PDBsum7tu7
PubMed35643313
UniProtA3XHN1

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