Structure of PDB 7ts3 Chain C

Receptor sequence
>7ts3C (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
FLKVKNWETEVVLTDTLHLKSTLETGCTEYICMGSIMHPSQHARRPEDVA
TKDQLFPLAKEFIDQYYSSIKRFGSKAHMERLEEVNKEIDTTSTYQLKDT
ELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYA
TNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANV
QFTEICIQQGWKPPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHP
KFEWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYC
DNSRYNILEEVAKKMNLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIV
DHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYR
LTPSFEYQPDPWNTHVWK
3D structure
PDB7ts3 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
ChainC
Resolution2.099 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.39: nitric-oxide synthase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C W414 R419 C420 F589 W592 E597 W683 F709 Y711 W110 R115 C116 F285 W288 E293 W379 F405 Y407
BS02 H4B C S339 R601 V682 W683 S35 R297 V378 W379
BS03 K7U C P570 V572 F589 W592 E597 P266 V268 F285 W288 E293
BS04 ZN C C331 C336 C27 C32
BS05 H4B C F696 H697 E699 F392 H393 E395
Gene Ontology
Molecular Function
GO:0004517 nitric-oxide synthase activity
Biological Process
GO:0006809 nitric oxide biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7ts3, PDBe:7ts3, PDBj:7ts3
PDBsum7ts3
PubMed35772285
UniProtP29475|NOS1_HUMAN Nitric oxide synthase 1 (Gene Name=NOS1)

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