Structure of PDB 7tfj Chain C

Receptor sequence
>7tfjC (length=330) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
EKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVDEGKLPHLLFYGPP
GTGKTSTIVALAREIYGKNYSNMVLELNASDDRGIDVVRNQIKDFASTRQ
IFSKGFKLIILDEADAMTNAAQNALRRVIERYTKNTRFCVLANYAHKLTP
ALLSRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDM
RRVLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDD
WGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLAD
IEYSISKGGNDQIQGSAVIGAIKASFENET
3D structure
PDB7tfj Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C G89 I90 R94 G84 I85 R89
BS02 AGS C V16 Y19 R20 P21 V27 Y28 G56 T57 G58 K59 T60 S61 N148 R206 V11 Y14 R15 P16 V22 Y23 G51 T52 G53 K54 T55 S56 N143 R201
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006260 DNA replication
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006272 leading strand elongation
GO:0006281 DNA repair
GO:0006298 mismatch repair
GO:0007064 mitotic sister chromatid cohesion
GO:0090618 DNA clamp unloading
Cellular Component
GO:0005634 nucleus
GO:0005663 DNA replication factor C complex
GO:0005829 cytosol
GO:0031389 Rad17 RFC-like complex
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7tfj, PDBe:7tfj, PDBj:7tfj
PDBsum7tfj
PubMed35829698
UniProtP38629|RFC3_YEAST Replication factor C subunit 3 (Gene Name=RFC3)

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