Structure of PDB 7tdv Chain C

Receptor sequence

>7tdvC (length=443) Species: 1280 (Staphylococcus aureus)

RTFTKEDIRKFVEEENVRYLRLQFTDILGTIKNVEVPVSQLEKVLDNEMM
FDGSSIEGFVRIEESDMYLHPDLDTWVIFPWTAGQGKVARLICDVYKTDG
TPFEGDPRANLKRVLKEMEDLGFTDFNLGPEPEFFLFKLDEKGEPTLELN
DDGGYFDLAPTDLGENCRRDIVLELEDMGFDIEASHHEVAPGQHEIDFKY
ADAVTACDNIQTFKLVVKTIARKHNLHATFMPKPLFGVNGSGMHFNVSLF
KGKENAFFDPNTEMGLTETAYQFTAGVLKNARGFTAVCNPLVNSYKRLVP
GYEAPCYIAWSGKNRSPLIRVPSSRGLSTRIEVRSVDPAANPYMALAAIL
EAGLDGIKNKLKVPEPVNQNIYEMNREEREAVGIQDLPSTLYTALKAMRE
NEVIKKALGNHIYNQFINSKSIEWDYYRTQVSEWERDQYMKQY

3D structure

• PDB: 7tdv Molecular dissection of the glutamine synthetase-GlnR nitrogen regulatory circuitry in Gram-positive bacteria.
• Chain: C
• Resolution: 2.92 Å

Enzymatic activity

• Enzyme Commision number: 6.3.1.2: glutamine synthetase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	C	G132 E134 E186 D200 F201 K202 Y203 N249 V250 S251 R323 S331 R333	G129 E131 E183 D197 F198 K199 Y200 N246 V247 S248 R320 S328 R330
BS02	P3S	C	E134 E136 E191 E198 G243 H247 R300 E306 R318	E131 E133 E188 E195 G240 H244 R297 E303 R315
BS03	MG	C	E136 E191 E198	E133 E188 E195
BS04	MG	C	E134 E198	E131 E195
BS05	MG	C	E134 H247 E335	E131 H244 E332

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0004356 glutamine synthetase activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006542 glutamine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:7tdv, PDBe:7tdv, PDBj:7tdv
• PDBsum: 7tdv
• PubMed: 35778410
• UniProt: E3VXC2